Sign up for Table of Contents Alerts.

Email this page

Print this page

Perspectives

The Ribosome Filter Redux

Vincent P. Mauro and Gerald M. Edelman

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.

The ribosome filter hypothesis postulates that ribosomes are not simply translation machines but also function as regulatory elements that differentially affect or filter the translation of particular mRNAs. On the basis of new information, we take the opportunity here to review the ribosome filter hypothesis, suggest specific mechanisms of action, and discuss recent examples from the literature that support it.

Authors

Vincent P. Mauro

The Scripps Research Institute; La Jolla, CA

Gerald M. Edelman

The Scripps Research Institute; La Jolla, CA

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.