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Brief Report
Cell Cycle-Dependent Induction of Autophagy, Mitophagy and Reticulophagy
Ezgi Tasdemir, M. Chiara Maiuri, Nicolas Tajeddine, Ilio Vitale, Alfredo Criollo, José Miguel Vicencio, John A. Hickman, Olivier Geneste and Guido Kroemer
volume 6 | issue 18
15 September 2007Pages: 2263 - 2267
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When added to cells, a variety of autophagy inducers that operate through distinct mechanisms and target different organelles for autophagic destruction (mitochondria in mitophagy, endoplasmic reticulum in reticulophagy) rarely induce autophagic vacuolization in more than 50% or the cells. Here we show that this heterogeneity may be explained by cell cycle-specific effects. The BH3 mimetic ABT737, lithium, rapamycin, tunicamycin or nutrient depletion stereotypically induce autophagy preferentially in the G1 and S phases of the cell cycle, as determined by simultaneous monitoring of cell cycle markers and the cytoplasmic aggregation of GFP-LC3 in autophagic vacuoles. These results point to a hitherto neglected crosstalk between autophagic vacuolization and cell cycle regulation.
Authors
Ezgi Tasdemir
Institut Gustave Roussy
M. Chiara Maiuri
INSERM U848; Villejuif, France
Nicolas Tajeddine
Institut Gustave Roussy
Ilio Vitale
INSERM; Villejuif, France
Alfredo Criollo
Institut Gustave Roussy
José Miguel Vicencio
Institut Gustave Roussy
John A. Hickman
Institut de Recherche Servier
Olivier Geneste
Institut de Recherche Servier
Guido Kroemer
INSERM; U848; Institut Gustave Roussy; Université Paris-Sud; Villejuif, France
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.