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COMMD1: A Novel Protein Involved in the Proteolysis of Proteins
Bart van de Sluis, Arjan J. Groot, Cisca Wijmenga, Marc Vooijs and Leo W. Klomp
volume 6 | issue 17
1 September 2007Pages: 2091 - 2098
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COMMD1 is a protein which is associated with multiple cellular pathways, including NFκB signaling, copper homeostasis and sodium transport. Recently we found that COMMD1 is also essential for normal mouse embryogenesis. Embryos deficient for Commd1 are retarded and die between 9.5 and 10.5 dpc. Increased HIF-1 activity and elevated HIF-1α protein expression were observed in 9.5 dpc Commd1-deficient embryos. In line with these in vivo data, in vitro studies showed that reduced COMMD1 expression caused increased HIF-1α protein stability and HIF-1 activity. Functional characterization of COMMD1 in NFκB signaling and ATP7B-dependent biliary copper excretion suggested that COMMD1 also has a role in regulating the protein degradation of RelA (p65) and ATP7B. The exact function of COMMD1 in these pathways remains elusive but these recent studies suggest that COMMD1 is associated with the ubiquitin-proteasomal system for regulating protein stability.
Authors
Bart van de Sluis
University Medical Center; Utrecht, The Netherlands
Arjan J. Groot
University Medical Center; Groningen, The Netherlands
Cisca Wijmenga
University Medical Center; Utrecht, The Netherlands
Marc Vooijs
University Medical Center; Utrecht, The Netherlands
Leo W. Klomp
University Medical Center; Utrecht, The Netherlands
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.