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R-Spondins in Cutaneous Biology: Nails and Cancer
Diana C. Blaydon, Michael P. Philpott and David P. Kelsell
volume 6 | issue 8
15 April 2007Pages: 895 - 897
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The R-spondins are a relatively recently identified family of secreted proteins linked to the Wnt signalling pathway. Recently, human phenotypes have been associated with mutations in two human R-spondins. Germline RSPO4 and RSPO1 mutations result in recessive anonychia (absence of all fingernails and toenails) and a recessive syndrome with XX-male sex reversal, PPK and a predisposition to SCC, respectively. This review discusses the key roles R-spondins play in embryogenesis, adult tissue maintenance and skin carcinogenesis.
Authors
Diana C. Blaydon
Queen Mary, University of London, London UK
Michael P. Philpott
Queen Mary, University of London, London UK
David P. Kelsell
Queen Mary, University of London, London UK
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.