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Perspectives
ATM and ATR: Components of an Integrated Circuit
Paula J. Hurley and Fred Bunz
volume 6 | issue 4
15 February 2007Pages: 414 - 417
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The phosphatidylinositol 3-kinase-like kinases (PIKKs) ATM and ATR activate a complex signaling network in response to diverse forms of DNA damage. Initial characterization of these signaling molecules focused on the individual role that each plays in response to specific types of DNA lesions. Recently, a more integrated view of the DNA-damage signaling network has emerged. ATM- and ATR-activated signaling pathways once appeared parallel, but new findings suggest that this cellular circuitry is highly interconnected. Communication between ATM and ATR enables the cell to respond to DNA strand breaks and inhibition of DNA synthesis with coordinated, highly modulated outputs. In this article, we focus on several new developments that give insight into the integrated processing of diverse signals that arise during the damage and replication of DNA.
Authors
Paula J. Hurley
Johns Hopkins University School of Medicine; Baltimore, Maryland USA
Fred Bunz
Johns Hopkins University School of Medicine; Baltimore, Maryland USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.