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Perspectives
Putting a Finger on Growth Surveillance: Insight into MDM2 Zinc Finger-Ribosomal Protein Interactions
Mikael S. Lindstrom, Chad Deisenroth and Yanping Zhang
volume 6 | issue 4
15 February 2007Pages: 434 - 437
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A number of events imparting instability to ribosomal biogenesis can cause nucleolar stress and trigger activation of a p53 checkpoint. Following nucleolar stress, ribosomal proteins L5, L11 and L23 bind to MDM2, blocking MDM2-mediated p53 ubiquitination and degradation. The MDM2 C4 zinc finger domain has been shown to play an important role in this process. Mutations targeting the C4 zinc finger of MDM2 have been reported in human cancers, and now a potential rationale for the occurrence of these mutations in cancer has emerged. Here we further discuss these findings and propose the existence of a Ribosomal Protein-MDM2-p53 surveillance network responsible for monitoring the stability of the transition between cell growth and division.
Authors
Mikael S. Lindstrom
University of North Carolina at Chapel Hill, Chapel Hill, NC
Chad Deisenroth
University of North Carolina at Chapel Hill, Chapel Hill, NC
Yanping Zhang
University of North Carolina at Chapel Hill, Chapel Hill, NC
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.