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Brief Report
CTCF Regulates Asynchronous Replication of the Imprinted H19/Igf2 Domain
Rosita Bergström, Joanne Whitehead, Sreenivasulu Kurukuti and Rolf Ohlsson
volume 6 | issue 4
15 February 2007Pages: 450 - 454
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Asynchronous replication during S phase is a universal characteristic of genomically imprinted genes. Replication timing in imprinted domains is determined epigenetically, as it is parent of origin specific, and is seen in the absence of sequence divergence between the two alleles. At the imprinted H19/Igf2 domain, the methylated paternal allele replicates early while the CTCF-bound maternal allele replicates late during S phase. CTCF regulates the allele-specific epigenetic characteristics of this domain, including methylation, transcription and chromosome conformation. Here we show that maternal, but not paternal inheritance of a mutated H19 imprinting control region, lacking functional CTCF binding sites, underlies a late to early switch in replication timing of the maternal H19/Igf2 domain.
Authors
Rosita Bergström
Uppsala University, Uppsala, Sweden
Joanne Whitehead
CNRS & Institut Curie, Paris, France
Sreenivasulu Kurukuti
The Babraham Institute, Cambridge, UK
Rolf Ohlsson
Uppsala University, Uppsala, Sweden
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.