Sign up for Table of Contents Alerts.
Email this page
Print this page
Spotlight on p63 (Guest Editors, Gerry Melino and Frank McKeon)
Key role of p63 in BMP-4-Induced Epidermal Commitment of Embryonic Stem Cells
Daniel Aberdam, Karen Gambaro, Philippe Rostagno, Edith Aberdam, Stéphanie de la Forest Divonne and Matthieu Rouleau
volume 6 | issue 3
1 February 2007Pages: 291 - 294
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
In vivo studies, transgenic and knock-out mice have demonstrated that p63 isoforms play pivotal roles in ectodermal and epidermal development but their respective function remains highly controversial. Since embryonic stem (ES) cells can be differentiated into many cell types, they represent an effective tool to recapitulate in vitro the main steps of embryonic development. We recently reported the efficient derivation of ectodermal and epidermal cells from murine ES cells and clarified the function of BMP-4 in the binary neuroectodermal choice by stimulating sox-1+ neural precursors to undergo specific apoptosis while inducing epidermal differentiation through ΔNp63 gene activation. ΔNp63 is not required for ectodermal fate but enhances ES-derived ectodermal cell proliferation and epidermal commitment. This unique cellular model should further provide a powerful tool for identifying the molecular mechanisms controlling normal skin development and in p63-ectodermal dysplasia human congenital pathologies.
Authors
Daniel Aberdam
INSERM; Nice, France
Karen Gambaro
INSERM; Nice, France
Philippe Rostagno
INSERM; Nice, France
Edith Aberdam
INSERM; Nice, France
Stéphanie de la Forest Divonne
INSERM; Nice, France
Matthieu Rouleau
INSERM; Nice, France
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.