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HIPK2, a Versatile Switchboard Regulating the Transcription Machinery and Cell Death
Marco A. Calzado, Florian Renner, Ana Roscic and M. Lienhard Schmitz
volume 6 | issue 2
15 January 2007Pages: 139 - 143
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Homeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase that regulates gene expression by phosphorylation of transcription factors and accessory components of the transcription machinery. HIPK2 is activated in response to DNA-damaging or morphogenic signals and accordingly HIPK2-guided gene expression programs trigger differentiation and development or alternatively apoptosis. The kinase contributes to the regulation of remarkably diverse pathways such as p53 activation or Wnt signaling. Here we discuss recent findings from biochemical and functional experiments that allow a deeper understanding of the pleiotropic effects mediated by HIPK2.
Authors
Marco A. Calzado
Institute of Biochemistry, Justus-Liebig University; Giessen, Germany
Florian Renner
Institute of Biochemistry, Justus-Liebig University; Giessen, Germany
Ana Roscic
Institute of Biochemistry, Justus-Liebig University; Giessen, Germany
M. Lienhard Schmitz
Institute of Biochemistry, Justus-Liebig University; Giessen, Germany
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.