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Perspectives
Proteolysis-Driven Oncogenesis
Vladislav S. Golubkov and Alex Y. Strongin
volume 6 | issue 2
15 January 2007Pages: 147 - 150
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An elevated expression of matrix metalloproteinases (MMPs) has been correlated with the growth and metastasis of pre-existing tumors. The latest data, however, suggest that MMPs, by promoting genomic instability, are directly involved in the early stages of cell transformation from normalcy to malignancy and in incipient cancer. Here, we discuss these novel findings and present a novel concept of a proteolysis-driven oncogenesis. We have placed the emphasis of our review on the membrane type-1 matrix metalloproteinase (MT1-MMP)-induced chromosome instability which leads to the transition from normalcy to malignancy.
Authors
Vladislav S. Golubkov
Burnham Institute for Medical Research, La Jolla, CA
Alex Y. Strongin
Burnham Institute for Medical Research, La Jolla, CA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.