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Perspectives
miRNAs Regulate miRNAs: Coordinated Transcriptional and Post-Transcriptional Regulation
Andrea Tuccoli, Laura Poliseno and Giuseppe Rainaldi
volume 5 | issue 21
1 november 2006Pages: 2473 - 2476
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microRNAs are short single-stranded RNA molecules that negatively regulate gene expression at post-transcriptional level. Recently it has been demonstrated that microRNAs are involved in many physiological processes, including differentiation and development. Moreover, this class of tiny regulators is drammatically involved in many pathological processes, like tumors and genetic diseases. A main issue is how microRNA processing and expression are regulated: thanks to recent findings, we are beginning to get insight into this critical aspect of microRNA biology, but we are far from understanding these processes in all their complexity. In particular, microRNA coordinated expression with other regulatory molecules, such as transcription factors, is still under investigation. We depleted microRNA 221 and 222 and found that the microRNA signature of Human Umbilical Vein Endothelial Cells was affected as a consequence: 9 microRNAs were up-regulated and 23 microRNAs were down-regulated. We propose a model in which a complex network involving co-expressed microRNAs and transcription factors is affected by single microRNA-variations, with the result that microRNA expression profile is in turn modified.
Authors
Andrea Tuccoli
Institute of Clinical Physiology, Pisa, Italy
Laura Poliseno
Institute of Clinical Physiology, Pisa, Italy
Giuseppe Rainaldi
Institute of Clinical Physiology, Pisa, Italy
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.