ZW10 Function in Mitotic Checkpoint Control, Dynein Targeting, and Membrane Trafficking: Is Dynein the Unifying Theme?

Richard B Vallee, Dileep Varma and Denis L Dujardin

volume 5 | issue 21

1 november 2006
Pages: 2447 - 2451

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ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in non-dividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.

Authors

Richard B Vallee

Columbia University, New York, NY

Dileep Varma

Columbia University, New York, NY

Denis L Dujardin

2Ecole Supérieure de Biotechnologie de Strasbourg, ILLKIRCH, France

We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link: