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Review
Targeting Cyclins and Cyclin-Dependent Kinases in Cancer: Lessons from Mice, Hopes for Therapeutic Applications in Humans
Young-mi Lee and Piotr Sicinski
volume 5 | issue 18
15 september 2006Pages: 2110 - 2114
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The activity of cyclins and their associated cyclin-dependent kinases (CDKs) is frequently deranged in human cancers. For this reason, cyclin-CDK complexes have been considered as very promising therapeutic targets in human malignancies. An obvious concern, however, is whether blocking cyclin-CDK function would preferentially affect cancer cells, but not normal, non-transformed cells. Two recent reports addressed the requirement for cyclin D1-CDK4 kinase in mouse development versus in neoplasia. These studies documented that the kinase activity of cyclin D1-CDK complexes is largely dispensable for normal development, but it is critically required for the initiation and maintenance of mammary carcinomas. Here we summarize the lessons learned from mouse knockout experiments, and discuss the utility of CDK inhibitors in therapy of human cancers, and possibly of other diseases.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.