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Partitioning Viral Genomes in Mitosis: Same Idea, Different Targets
Alison A. McBride, Jaquelline G. Oliveira and Maria G. McPhillips
volume 5 | issue 14
15 july 2006Pages: 1499 - 1502
This is an open-access article
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Papillomavirus infections are long-lived and persistent. The circular DNA of the viral genome is maintained in dividing epithelial cells as an extrachromosomal element. The E2 protein of the virus binds to the viral genome and tethers it to mitotic chromosomes to ensure that the genome is retained and faithfully partitioned in dividing cells. This mechanism has been best studied for bovine papillomavirus type 1. Recent evidence indicates that while this is a common strategy among papillomaviruses, different viruses have evolved different chromosomal targets.
This is an open-access article
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.