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Review
The Taxol Pharmacophore and the T-Taxol Bridging Principle
David G. I. Kingston, Susan Bane and James P. Snyder
volume 4 | issue 2
february 2005Pages: 279 - 289
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Different approaches to developing an accurate model of the binding conformation of paclitaxel (TaxolTM, PTX) on ?-tubulin are discussed. Electron crystallography, molecular modeling, NMR and synthetic studies all point to the T-Taxol conformation as the bioactive form. The range of molecular designs represented by synthetic taxoids prepared to test the latter, with an emphasis on internally bridged analogs, is summarized. Key implications and conclusions derived from the retrospective are presented.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.