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Perspectives
Inflammatory Hypoxia: Role of Hypoxia-Inducible Factor
Jörn Karhausen, Volker H. Haase and Sean P. Colgan
volume 4 | issue 2
february 2005Pages: 256 - 258
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Sites of inflammation are characterized by significant changes in metabolic activity. Shifts in energy supply and demand can result in diminished delivery and/or avai lability of oxygen, leading to inflammation-associated tissue hypoxia and metabolic acidosis. These shifts in tissue metabolism, as indicated by previous studies, are frequently associ ated with vasculitis and profound recruitment of inflammatory cell types, particularly myeloid cells such as neutrophils ( PMN) and monocytes. Here, we review recent work addressing the influence of hypoxia on development of inflammatory lesions, with particular emphasis on molecular pathways regulated by hypoxia-inducible factor (HIF).
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.