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RhoH GTPase: A Key Regulator of Hematopoietic Cell Proliferation and Apoptosis?
Yi Gu, Yi Zheng and David A. Williams
volume 4 | issue 2
february 2005Pages: 201 - 202
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Rho GTPases are well characterized as critical regulators of cell growth and actin cytoskeleton in eukaryotic cells. The RhoE/Rnd3 subfamily member RhoH is hematopoietic-specific and GTPase deficient and thus is expected to be in the constitutively active, GTP-bound conformation. The activity of RhoH is likely regulated by the level of expression rather than GTP-binding/GTP-hydrolysis cycle in the cell. By RNAi based knockdown and overexpression approaches we recently have shown in hematopoietic progenitor cells that RhoH negatively impacts on growth factor-induced proliferation and survival and modulates chemokine-induced actin reorganization and cell migration. In addition, RhoH appears to counteract Rac GTPase activities, suggesting a possible mechanism by which RhoH functions as an antagonist of Rac signaling in the regulation of cell growth and actin-based functions in blood lineages.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.