Landes Bioscience

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September 2007

volume 6| issue 9

Editor's Corner

Cover Image

Volume: 6 | Issue: 9

News

Identification of Mutations in LKB1 and a Role for the Gene in Suppression of Lung Cancer

Volume: 6 | Issue: 9 | Pages: 1335 - 1336

Molecular Links Between IKKbeta, TSC1, mTOR and VEGF Provide Mechanism of Crosstalk Between Inflammatory Pathway and Angiogenic Switch

Volume: 6 | Issue: 9 | Pages: 1335 - 1336

Novel Oncogenic Gene Fusions in Prostate Cancer

Volume: 6 | Issue: 9 | Pages: 1337 - 1338

MiRNA34, Regulated by p53, is Lost in Lung Cancer

Volume: 6 | Issue: 9 | Page 1338

Does Everyone Need a Genetic Test Before Taking Irinotecan?

Volume: 6 | Issue: 9 | Pages: 1338 - 1339

Splice Variant of XBP1, an Estrogen Receptor-Interacting Protein, is Linked to Tamoxifen Resistance

Volume: 6 | Issue: 9 | Pages: 1340 - 1341

Does Blocking VEGF from the Inside or the Outside of the Cell Make a Difference?

Volume: 6 | Issue: 9 | Pages: 1340 - 1341

Death Proteins Required for T-cell Maturation Promote Cell Proliferation and Mitochondrial ROS Production

Volume: 6 | Issue: 9 | Page 1341

Diabetes Drug Metformin Activates AMPK, Increases Glycolysis, Inhibits Oxidative Phosphorylation and Selectively Reduces Growth of p53-Deficient Tumors in Mice

Volume: 6 | Issue: 9 | Page 1341

Five New Research Programs to Receive Funding from the Samuel Waxman Cancer Research Foundation

Volume: 6 | Issue: 9 | Pages: 1342 - 1343

Novel Method Developed to Study Blood Vessels in Disease State

Volume: 6 | Issue: 9 | Pages: 1343 - 1344

Review

Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

Jürgen Mattern, Markus W. Büchler and Ingrid Herr
Volume: 6 | Issue: 9 | Pages: 1345 - 1354

Journal Club

MDA-MB-435: The Questionable Use of a Melanoma Cell Line as a Model for Human Breast Cancer is Going On

Matthias Christgen and Ulrich Lehmann
Volume: 6 | Issue: 9 | Pages: 1355 - 1357

Androgen Receptor Modulation: Lessons Learned from Beyond the Prostate

Nima Sharifi and William D. Figg
Volume: 6 | Issue: 9 | Pages: 1358 - 1359

Clinical Study

Preclinical and Clinical Studies With the Multi-Kinase Inhibitor CEP-701 as Treatment for Prostate Cancer Demonstrate the Inadequacy of PSA Response as a Primary Endpoint

Connie Collins, Michael A. Carducci, Mario A. Eisenberger, John T. Isaacs, Alan W. Partin, Roberto Pili, Victoria J. Sinibaldi, Janet S. Walczak and Samuel R. Denmeade
Volume: 6 | Issue: 9 | Pages: 1360 - 1367

Clinical Case Report

Irinotecan Chemotherapy During Valproic Acid Treatment: Pharmacokinetic Interaction and Hepatotoxicity

Floris A. de Jong, Jessica M. van der Bol, Ron H. J. Mathijssen, Walter J. Loos, Ron A.A. Mathot, Jos J.E.M. Kitzen, Martin J. van den Bent and Jaap Verweij
Volume: 6 | Issue: 9 | Pages: 1368 - 1374

Research Paper

PKCη Expression Contributes to the Resistance of Hodgkin's Lymphoma Cell Lines to Apoptosis

Sara Abu-Ghanem, Galia Oberkovitz, Daniel Benharroch, Jacob Gopas and Etta Livneh
Volume: 6 | Issue: 9 | Pages: 1375 - 1380

Anti-Proliferative Effect of Ursolic Acid on Multidrug Resistant Hepatoma Cells R-HepG2 by Apoptosis Induction

Dong-Mei Zhang, Patrick Ming-Kuen Tang, Judy Yuet-Wa Chan, Hung-Ming Lam, Shannon Wing-Ngor Au, Siu-Kai Kong, Stephen Kwok-Wing Tsui, Mary Mui-Yee Waye, Thomas Chung-Wai Mak and Kwok-Pui Fung
Volume: 6 | Issue: 9 | Pages: 1381 - 1389

Systemic and Skin Toxicity in Cercopithecus aethiops sabaeus Monkeys Treated During 26 Weeks with a High Intravenous Dose of the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Nimotuzumab

Maria Elene Arteaga, Nuris Nuris Ledon, Angel Casaco, Balia Pardo, Miriam Garcia, Magela Boleda, Lisel Vina, Romy Orphee, Osvaldo Hernandez, Consuelo Gonzalez, Dasha Fuentes, Valia Rodriguez, Lidia Charro, Farah Baro, Amparo Macias, Aylen Perez, Yakelin Morales, Nelvys Subiros, Barbara Gonzalez, Mayra Ramos, Leyanis Rodriquez, Alcides Ballester-Labrada and Tania Crombet
Volume: 6 | Issue: 9 | Pages: 1390 - 1395

Single-Photon Emission Computed Tomography Imaging With a Humanized, Apoptosis-Inducing Antibody Targeting Human Death Receptor 5 in Pancreas and Breast Tumor Xenografts

Hyunki Kim, Tandra R. Chaudhuri, Donald J. Buchsbaum, Deli Wang and Kurt R. Zinn
Volume: 6 | Issue: 9 | Pages: 1396 - 1402

Expression Changes in EZH2, But Not in BMI-1, SIRT1, DNMT1 or DNMT3B are Associated with DNA Methylation Changes in Prostate Cancer

Michele J. Hoffmann, Rainer Engers, Andrea R. Florl, Arie P. Otte, Mirko Muller and Wolfgang A. Schulz
Volume: 6 | Issue: 9 | Pages: 1403 - 1412

Anthracenedione Derivative 1403P-3 Induces Apoptosis in KB and KBv200 Cells Via Reactive Oxygen Species-Independent Mitochondrial Pathway and Death Receptor Pathway

Jian-ye Zhang, Hai-ying Wu, Xue-kui Xia, Yong-ju Liang, Yan-yan Yan, Zhi-gang She, Yong-cheng Lin and Li-wu Fu
Volume: 6 | Issue: 9 | Pages: 1413 - 1421

mDia Function is Critical for the Cell Suicide Program Triggered by Farnesyl Transferase Inhibition

Uma Kamasani, James B. DuHadaway, Arthur S. Alberts and George C. Prendergast
Volume: 6 | Issue: 9 | Pages: 1422 - 1427

Indomethacin Enhances the Cytotoxicity of Recombinant Human Lymphotoxin α on Tumor Cells by Suppressing NF-κB Signaling

Yijun Shen, Tong Yang, Jing Wang, Qing Xu, Rong Li, Wei Pan, Gang Li, Zheng Wang, Jingwei Tan, Jinsong Wu, Fang Wu, Luochun Wang and Yanjun Liu
Volume: 6 | Issue: 9 | Pages: 1428 - 1433

Bone Marrow Renin-Angiotensin System Expression In Polycythemia Vera And Essential Thrombocythemia Depends On JAK2 Mutational Status

Maruska Marusic Vrsalovic, Vlatko Pejsa, Tajana Stoos Veic, Slobodanka Ostojic Kolonic, Radmila Ajdukovic, Visnja Haris, Ozren Jaksic and Rajko Kusec
Volume: 6 | Issue: 9 | Pages: 1434 - 1436

Raf Inhibitor Stabilizes Receptor for the Type I Interferon But Inhibits its Anti-Proliferative Effects in Human Malignant Melanoma Cells

K.G. Suresh Kumar, Jianghuai Liu, Ying Li, Duonan Yu, Andrei Thomas-Tikhonenko, Meenhard Herlyn and Serge Y. Fuchs
Volume: 6 | Issue: 9 | Pages: 1437 - 1441

Correlation Between Hybrid 18F-FDG PET/CT and Apoptosis Induced by Neoadjuvant Chemotherapy in Breast Cancer

Dong Li, Qing Yao, Liwen Li, Ling Wang and Jianghao Chen
Volume: 6 | Issue: 9 | Pages: 1442 - 1448

VSL#3 Probiotic Treatment Reduces Chemotherapy-Induced Diarrhoea and Weight Loss

Joanne M Bowen, Andrea M Stringer, Rachel J Gibson, Ann SJ Yeoh, Sarah Hannam and Dorothy MK Keefe
Volume: 6 | Issue: 9 | Pages: 1449 - 1454

The Functional Effects of Acid Ceramidase Over-Expression in Prostate Cancer Progression and Resistance to Chemotherapy

Antonio F. Saad, William D. Meacham, Aiping Bai, Viviane Anelli, Viviane Anelli, Ayman E.M. Mahdy, Lorianne S. Turner, Joe Cheng, Alicja Bielawska, Jacek Bielawski, Thomas E. Keane, Lina M. Obeid, Yusuf A. Hannun, James S. Norris and Xiang Liu
Volume: 6 | Issue: 9 | Pages: 1455 - 1460

Potentiation of the Antitumor Effects of Both Selective Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors in Human Hepatic Cancer Cells by Inhibition of the MEK/ERK Pathway

Antonella Cusimano, Daniela Foderà, Natale D'Alessandro, Nadia Lampiasi, Antonina Azzolina, Giuseppe Montalto and Melchiorre Cervello
Volume: 6 | Issue: 9 | Pages: 1461 - 1468

Chemotherapy-Resistant Side-Population of Colon Cancer Cells has a Higher Sensitivity to TRAIL than the Non-SP, a Higher Expression of c-Myc and TRAIL-Receptor DR4

Robyn T. Sussman, M. Stacey Ricci, Lori S. Hart, Shi Yong Sun and Wafik S. El-Deiry
Volume: 6 | Issue: 9 | Pages: 1490 - 1495

Workshop Report

Tumor Cell Dormancy: An NCI Workshop Report

Robert L. Vessella, Klaus Pantel and Suresh Mohla
Volume: 6 | Issue: 9 | Pages: 1496 - 1504

Open Access Article

Profiles and Legacies

Hasan Mukhtar

Volume: 6 | Issue: 9 | Pages: 1505 - 1508

Table of Contents

September 2007

volume 6| issue 9

Editor's Corner

Cover Image

News

Identification of Mutations in LKB1 and a Role for the Gene in Suppression of Lung Cancer

Molecular Links Between IKKbeta, TSC1, mTOR and VEGF Provide Mechanism of Crosstalk Between Inflammatory Pathway and Angiogenic Switch

Novel Oncogenic Gene Fusions in Prostate Cancer

MiRNA34, Regulated by p53, is Lost in Lung Cancer

Does Everyone Need a Genetic Test Before Taking Irinotecan?

Splice Variant of XBP1, an Estrogen Receptor-Interacting Protein, is Linked to Tamoxifen Resistance

Does Blocking VEGF from the Inside or the Outside of the Cell Make a Difference?

Death Proteins Required for T-cell Maturation Promote Cell Proliferation and Mitochondrial ROS Production

Diabetes Drug Metformin Activates AMPK, Increases Glycolysis, Inhibits Oxidative Phosphorylation and Selectively Reduces Growth of p53-Deficient Tumors in Mice

Five New Research Programs to Receive Funding from the Samuel Waxman Cancer Research Foundation

Novel Method Developed to Study Blood Vessels in Disease State

Review

Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

Journal Club

MDA-MB-435: The Questionable Use of a Melanoma Cell Line as a Model for Human Breast Cancer is Going On

Androgen Receptor Modulation: Lessons Learned from Beyond the Prostate

Clinical Study

Preclinical and Clinical Studies With the Multi-Kinase Inhibitor CEP-701 as Treatment for Prostate Cancer Demonstrate the Inadequacy of PSA Response as a Primary Endpoint

Clinical Case Report

Irinotecan Chemotherapy During Valproic Acid Treatment: Pharmacokinetic Interaction and Hepatotoxicity

Research Paper

PKCη Expression Contributes to the Resistance of Hodgkin's Lymphoma Cell Lines to Apoptosis

Anti-Proliferative Effect of Ursolic Acid on Multidrug Resistant Hepatoma Cells R-HepG2 by Apoptosis Induction

Systemic and Skin Toxicity in Cercopithecus aethiops sabaeus Monkeys Treated During 26 Weeks with a High Intravenous Dose of the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Nimotuzumab

Single-Photon Emission Computed Tomography Imaging With a Humanized, Apoptosis-Inducing Antibody Targeting Human Death Receptor 5 in Pancreas and Breast Tumor Xenografts

Expression Changes in EZH2, But Not in BMI-1, SIRT1, DNMT1 or DNMT3B are Associated with DNA Methylation Changes in Prostate Cancer

Anthracenedione Derivative 1403P-3 Induces Apoptosis in KB and KBv200 Cells Via Reactive Oxygen Species-Independent Mitochondrial Pathway and Death Receptor Pathway

mDia Function is Critical for the Cell Suicide Program Triggered by Farnesyl Transferase Inhibition

Indomethacin Enhances the Cytotoxicity of Recombinant Human Lymphotoxin α on Tumor Cells by Suppressing NF-κB Signaling

Bone Marrow Renin-Angiotensin System Expression In Polycythemia Vera And Essential Thrombocythemia Depends On JAK2 Mutational Status

Raf Inhibitor Stabilizes Receptor for the Type I Interferon But Inhibits its Anti-Proliferative Effects in Human Malignant Melanoma Cells

Correlation Between Hybrid 18F-FDG PET/CT and Apoptosis Induced by Neoadjuvant Chemotherapy in Breast Cancer

VSL#3 Probiotic Treatment Reduces Chemotherapy-Induced Diarrhoea and Weight Loss

The Functional Effects of Acid Ceramidase Over-Expression in Prostate Cancer Progression and Resistance to Chemotherapy

Potentiation of the Antitumor Effects of Both Selective Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors in Human Hepatic Cancer Cells by Inhibition of the MEK/ERK Pathway

Open Access Article

Diffusion-Weighted and Macromolecular Contrast Enhanced MRI of Tumor Response to Antivascular Therapy with ZD6126

Lung Cancer: An Organized Cellular and Metabolic Domain

Mutant TNF-α Negatively Regulates Human Breast Cancer Stem Cells from MCF7 in vitro

Chemotherapy-Resistant Side-Population of Colon Cancer Cells has a Higher Sensitivity to TRAIL than the Non-SP, a Higher Expression of c-Myc and TRAIL-Receptor DR4

Workshop Report

Tumor Cell Dormancy: An NCI Workshop Report

Open Access Article

Profiles and Legacies

Hasan Mukhtar