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Review
Interference of Glucocorticoids with Apoptosis Signaling and Host-Tumor Interactions
Hans Peter Rutz and Ingrid Herr
volume 3 | issue 8
august 2004Pages: 715-718
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The cure of cancer is compromised by a variety of factors and mechanisms, which include tissue origin of the malignant cells, tumor load and hypoxia, impediment of drug access, and cellular resistance to treatment. Treatment resistance may be intrinsic, acquired, or induced, and it may occur to either radiation or a single drug alone, or simultaneously to multiple agents. Although the problem of corticosteroid-induced and hence, iatrogenic resistance to the treatment of cancer has continuously gained some interest over the past several years, no measures have been taken yet to diligently examine this problem in the clinical situation. In this review, we address several additional mechanisms through which glucocorticoids may influence the result of cytotoxic therapy of cancer, like: inducible interference with apoptosis signaling; interference with immune response against malignant cells; as well as issues relating to their impact on glucose metabolism in cancer patients.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.