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Exegeses
Four Birds with One Stone: RAPA as Potential Anticancer
Mikhail V. Blagosklonny and Zbigniew Darzynkiewicz
volume 1 | issue 4
July/August 2002Pages: 359-361
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By demonstrating antiangiogenic effects of low doses of rapamycin, a recent article in Nature Medicine allows us to conceptually connect antiangiogenic therapy with protection of normal cells for selective targeting of cancer cells. We discuss how the same agent can be chosen to target either normal cells (to inhibit angiogenesis and to protect normal cells from chemotherapy) or cancer cells (to prevent hypoxia-resistance and to suppress ‘target-dependent’ cancer cells).
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.