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Review
Id Proteins - Tumor Markers or Oncogenes?
Jens Hasskarl and Karl Münger
volume 1 | issue 2
March/April 2002Pages: 091-096
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The Id (Inhibitor of differentiation or Inhibitor of DNA-binding) proteins act as dominant negative inhibitors of differentiation-specific basic Helix-Loop-Helix (bHLH) transcription factors. Id proteins negatively regulate cellular differentiation and they induce proliferation by modulating different cell cycle regulators both by direct and indirect mechanisms. Ectopic expression of Id proteins in tissue culture models can result in cellular immortalization and abrogation of differentiation processes. Recent reports show that Id proteins are overexpressed in various cancer types implying a role of these regulatory proteins in carcinogenesis. This review focuses on the biology of the Id proteins and their role as potential oncogenes.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.