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Research Paper
SEPT9_V1 Protein Expression is Associated with Human Cancer Cell Resistance to Microtubule Disrupting Agents
Sharon Amir and Nicola J. Mabjeesh
volume 6 | issue 12
December 2007Pages: 1926 - 1931
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SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1α, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents
Authors
Sharon Amir
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Nicola J. Mabjeesh
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel