Prostaglandin E2: At the Crossroads Between Stem Cell Development, Inflammation and Cancer

Caitlin Marie Logan, Antonio Giordano, Andrew Puca and Marco Cassone

volume 6 | issue 10

October 2007
Pages: 1517 - 1521

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Stem cells have tremendous therapeutic potential for a series of pathologies ranging from cancer to genetic diseases. The obstacles to exploiting their potential reside mainly in their limited numbers or potency. Prostaglandins are known to be involved in many physiological and pathological processes. Among these, their importance in stem cell development is just starting to emerge. The recent findings by North and colleagues (Nature, 2007; 447:1007-1011) uncover a crucial role for PGE2 in hematopoietic stem cell growth and development not only in embryonic, but also in adult stem cell homeostasis in both simple and complex vertebrate systems. This new information adds to recent advances in the study of PGE2’s role in many diseases and in the reaction to various cellular stress conditions. This is the perfect time to improve our knowledge of stem cell regulation, which hopefully will lead to improved stem cell-based therapeutic options and also to better understand and manage current anti-inflammatory and immuno-suppressive drugs in the therapy of cancer and other diseases.

Authors

Caitlin Marie Logan

Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA; Smith College, Northampton, MA, USA

Antonio Giordano

Sbarro Institute for Cancer Research and Molecular Medicine, Philadelphia PA, USA

Andrew Puca

Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA

Marco Cassone