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Journal Club
Taming NEMO to Slay Cancer Cells
Kimberly A. Scata and Wafik S. El-Deiry
volume 5 | issue 9
september 2006Pages: 1096 - 1097
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In order to increase the efficacy of chemotherapy, it is necessary to first understand the forces that act to promote cell survival in the face of cellular damage. The NF-κB pathway plays a clear role in mediating cell survival in response to DNA damage, acting in opposition to pro-apoptotic signals. How this pathway is regulated has been less clear. Recent studies have shed light on the intersection of DNA damaging pathways and the NF-κB signal transduction cascade. Wu and colleagues (Science 311:1141-1146, 2006) demonstrate that ATM directly phophorylates NEMO in response to DNA damage. ATM then is carried into the cytoplasm with NEMO allowing for the activation of IKK and thus NF-κB activation.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.