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Editor's Corner
Cover Image
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volume 5 | issue 6
june 2006Pages: NA A PDF is not yet available for this article.
The cover image shows immunohistochemical staining for SMAD4 protein expression (brown color) in an archived primary breast tumor. While this tumor expresses SMAD4 protein, Zhong et al., in this issue of Cancer Biology and Therapy, demonstrate that biallelic inactivation of SMAD4 through homozygous deletion does occur in a small percentage of invasive ductal carcinomas. Their findings support the hypothesis that inactivation of SMAD4 signaling plays a role in the development of a subset of breast cancers.
A PDF is not yet available for this article.