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Review
MicroRNA Trafficking and Human Cancer
Junming Yue and Gabor Tigyi
volume 5 | issue 6
june 2006Pages: 573-578
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MicroRNAs (miRNAs) are short endogenous non-coding small RNA molecules with 21 to 25 nucleotides (nt) in length, which negatively regulate gene expression either by degrading specific mRNA or impeding translation at the transcriptional and posttranscriptional level. Recent advances suggest that miRNAs play prominent roles in development, genome organization, viral and transposon defense, and human disease, including neurodegenerative and metabolic diseases. Surprisingly, miRNAs are now linked with a variety of cancers, in which a reduced expression or over-expression may lead to oncogene or tumor suppressor gene-like actions. Here we will overview the miRNA pathway and its regulation with emphasis on the links with human cancer. Finally potential applications of miRNA in tumor diagnosis and therapy will be discussed.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.