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Editor's Corner

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Thioredoxin reductase 1 (TrxR1) is a cytosolic enzyme that plays a central role in controlling cellular redox homeostasis and can impact on transformation, invasion, metastasis and resistance to therapy. The image shows HepG2 cells that were transfected with siTrxR1 RNA and assayed for the presence of apoptosis with Annexin V-EGFP (green signal) and Propidium Iodide (red signal). Dead cells are indicated by arrowheads (Annexin V positive-Propidium Iodide positive); apoptotic cells are indicated by arrows (Annexin V positive-Propidium Iodide negative). Additional details of the studies of Gorreta et al. identifying TrxR1-dependent genes and a role in IFN-beta/ATRA responses can be found in the current issue of Cancer Biology & Therapy.