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Research Paper
Post-Biopsy Rise in Serum PSA : A Potential Tool for the Dynamic Evaluation of Prostate Cancer/Prostatic Intraepithelial Neoplasia (PIN)
Shiv Bhanot, R. Gopalakrishnan and R.T.D. Oliver
volume 2 | issue 1
January/February 2003Pages: 067-070
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Objectives. The biochemical response of prostatic cells to needle core
biopsies is known to manifest as a rise in serum PSA. The aim of this study
is to evaluate the PSA response to mechanical trauma in prostate cancer patients,
when compared to benign controls.
Materials and Methods. 50 consecutive patients undergoing transrectal
ultrasound guided prostatic needle biopsies had their total serum PSA measured
thirty minutes after the procedure. Change from the baseline PSA was estimated
and correlated to histology.
Results. Data was analysed in 48 patients (mean age 68 years; range 55-87
years). Histology showed benign, cancer and PIN results in 24, 19 and 5 patients
respectively. The highest rise in post biopsy PSA was observed in the PIN group.
A significant difference in the rise in serum PSA was noted between controls
and the cancer group. Conclusion. Post biopsy PSA response differs significantly
between benign and malignant prostatic tissue. PIN causes an excessive rise
in PSA values on mechanical stimulation. This small study indicates that the
biopsy model may help us to assess the dynamics of prostate cancer.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.