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Journal Club
T Regulatory Cell Depletion Can Boost DC-Based Vaccines
Fabian Benencia and George Coukos
volume 4 | issue 6
june 2006Pages: 628-630
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Dendritic cells loaded with tumor antigen have been proposed as effective therapeutic vaccines in different tumor models. Now, in the Journal of Immunology 2005; 174: 90-98, a study by Prasad et al., report that depletion of regulatory T cells prior to immunization can enhance the potency of DC-based vaccines without inducing autoimmune responses in a mouse model of melanoma. This vaccination strategy can be readily applied to general therapeutic vaccination settings.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.