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Review
Nuclear Positioning, Gene Activity, and Cancer
Valentina Guasconi, Mouloud Souidi, Slimane Ait-Si-Ali
volume 4 | issue 2
February 2005Pages: 134-138
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In the interphasic nucleus chromosomes are non-randomly arranged within the nuclear space. Indeed, chromosomes are thought to be organised into “chromosome territories”. The size of a chromosome territory is roughly determined by its DNA content, but is also influenced by other constituents, such as their transcriptional status. Chromatin modifications and positioning of genetic loci in the nucleus plays a critical role in the control of gene expression. Emerging evidence suggests that the nucleus is structurally and functionally compartimentalized and desorganization of such a structure might play a major role in the emergence of human diseases such as cancer.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.