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Research Paper
Unpulsed Dendritic Cells Induce Broadly Applicable Anti-Tumor Immunity in Mice
Grzegorz Dworacki, Vito R. Cicinnati, Susanne Beckebaum, Eva Pizzoferrato, Thomas K. Hoffmann, Albert B. De Leo
volume 4 | issue 1
january 2005Pages: 050-056
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The discovery of dendritic cells (DC) as professional antigen presenting cells has opened up new possibilities for their use in the development of cancer vaccines. Here we show that unpulsed BM-derived CD11c+CD87alpha;-+ DC administered s.c. to mice enhanced their resistance to subsequent lethal tumor challenges. The tumor resistance-inducing activity of unpulsed DC was dependent on their maturation status, involved CD4+ and CD8+ T cell activities, and was abrogated by pulsing with an irrelevant class I MHC-restricted peptide. Although the BALB/c Meth A tumor system was employed extensively to demonstrate the tumor resistance inducing activity of unpulsed DC, the immunogenicity of this vaccine was evident in other inbred strains of mice against a variety of syngeneic tumors. The broad anti-tumor responses induced by unpulsed DC appears to be due to their capacity to present “self” tumor-associated antigens, such as the H2-Kd-restricted, wild type sequence p53232-240 peptide. These findings highlight the potential broad applicability of unpulsed DC as a tumor vaccine.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.