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Review Series: The Role of Autophagy During Ischemia/Reperfusion

Autophagic neuron death in neonatal brain ischemia/hypoxia

Yasuo Uchiyama, Masato Koike and Masahiro Shibata

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Hypoxia/ischemia (H/I) brain injury at birth is an important cause of cerebral palsy, mental retardation, and epilepsy. The H/I insult also causes energy failure, oxidative stress, and unbalanced ion fluxes, leading to high induction of autopahgy in brain neurons. Since the mice unable to execute autophagy (due to brain-specific deletion of Atg7 or Atg5) die by massive loss of cerebral and cerebellar neurons with accumulation of ubiquitin aggregates, induction of neuronal autophagy after H/I injury is generally considered neuroprotective by maintaining cellular homeostasis. However, our recent results show that hippocampal pyramidal neurons undergoing caspase-dependent or -independent death following neonatal H/I injury possess abundant LC3-positive granules, and such H/I neuronal death is largely prevented by Atg7 deficiency. In the present review we discuss the roles of autophagy and other forms of programmed cell death in the neonatal H/I brain insult.

Authors

Yasuo Uchiyama

Osaka University Graduate School of Medicine

Masato Koike

Osaka University Graduate School of Medicine

Masahiro Shibata

Osaka University Graduate School of Medicine

Purchase article for $19

Subscribe to this journal for $99/year