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Review
Autophagy and Vacuole Homeostasis: A Case for Self-Degradation?
Dalibor Mijaljica, Mark Prescott, Daniel J. Klionsky and Rodney J. Devenish
volume 3 | issue 5
September/October 2007Pages: 417 - 421
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The vacuole of yeast plays an important role in pH- and ion-homeostasis. Another important function of the vacuole, especially during nutrient deprivation, is the degradation of proteins, other macromolecules and organelles. To deliver these components into the vacuolar lumen, specific and sophisticated transport pathways such as autophagy have evolved. This review will first look at autophagy and its relationship to vacuole homeostasis, then move to the topic of vacuole self-degradation and possible reasons for its existence, and close by pointing very briefly to some areas for further research in these topics.
Authors
Dalibor Mijaljica
Monash University
Mark Prescott
Monash University
Daniel J. Klionsky
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, and Department of Biological Chemistry; University of Michigan; Ann Arbor, Michigan USA
Rodney J. Devenish
Monash University
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.