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Article Addendum
Role of Autophagy in Innate Viral Recognition
Akiko Iwasaki
volume 3 | issue 4
July/August 2007Pages: 354 - 356
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Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes via Toll-like receptors (TLRs) upon endocytosis of virions. Yet, pDC responses to certain single-stranded RNA viruses occur only following live viral infection. In our recent study, we presented evidence that the recognition of such viruses by TLR7 requires autophagy. We speculate that the requirement for autophagy in viral recognition reflects the necessity for transportation of cytosolic viral replication intermediates into the lysosome where TLR7 is activated. In addition, autophagy was found to be required for pDCs to produce type I interferon (IFN) in response to both ssRNA and dsDNA viruses. These results indicated that autophagy plays a key role in mediating virus detection and IFNα secretion in pDCs, and suggest that cytosolic replication intermediates of ssRNA viruses serve as pathogen signatures recognized by TLR7.
Addendum to:
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells
H.K. Lee, J.M. Lund, B. Ramanathan, N. Mizushima and A. Iwasaki
Science 2007; In press
Authors
Akiko Iwasaki
Yale University School of Medicine
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.