Sign up for Table of Contents Alerts!
Email this page
Print this page
Article Addendum
Nitric Oxide-Induced Cell Death in the Heart: The Role of Autophagy
Simon W. Rabkin
volume 3 | issue 4
July/August 2007Pages: 347 - 349
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
There is unequivocal evidence of autophagy in the heart, both in human hearts from patients who experienced heart failure and in experimental models of myocardial ischemia and reperfusion. Whether autophagy is involved in the pathophysiology of these conditions is controversial as studies suggest inhibition of Beclin 1 can increase or decrease cardiomyocyte cell injury. Increased beclin 1 expression, however, has been consistently identified in myocardial ischemia/reperfusion. Because of the role of nitric oxide (NO) in myocardial ischemia/reperfusion as well as in heart failure, we sought to determine whether NO and its byproduct peroxynitrite alter the expression of some genes involved in autophagy in the heart.
Addendum to:
Nitric Oxide Differentially Regulates the Gene Expression of Caspase Genes but Not Some Autophagic Genes
S.W. Rabkin and S.S. Klassen
Nitric Oxide 2007; In press
Authors
Simon W. Rabkin
University of British Columbia
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.