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Research Paper
Selective and Non-Selective Autophagic Degradation of Mitochondria in Yeast
Ingrid Kiššová, Bénédicte Salin, Jacques Schaeffer, Sapan Bhatia, Stephen Manon and Nadine Camougrand
volume 3 | issue 4
July/August 2007Pages: 329 - 336
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Mitochondria are essential to oxidative energy production in aerobic eukaryotic cells, where they are also required for multiple biosynthetic pathways to take place. Mitochondrial homeostasis also plays a crucial role in ageing and programmed cell death, and recent data have suggested that mitochondria degradation is a strictly regulated process. Autophagy is an evolutionary conserved mechanism that provides cells with a mechanism for the continuous turnover of damaged and obsolete macromolecules and organelles. In this work, we investigated mitochondria degradation by autophagy. Electron microscopy observations of yeast cells submitted to nitrogen starvation after growth on different carbon sources provided evidence that microautophagy, rather than macroautophagy, preferentially occurred in cells grown under non-fermentable conditions. The observation of mitochondria degradation showed that both a selective process and a non-selective process of mitochondria autophagy occurred successively. In a yeast strain inactivated for the gene UTH1, the selective process was not observed.
Authors
Ingrid Kiššová
comenius university
Bénédicte Salin
CNRS
Jacques Schaeffer
CNRS
Sapan Bhatia
Princeton University
Stephen Manon
CNRS
Nadine Camougrand
Université de Bordeaux 2
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.