Nanoparticles as a Novel Class of Autophagy Activators

Olga Zabirnyk, Maksym Yezhelyev and Oleksandr Seleverstov

volume 3 | issue 3

May/June 2007
Pages: 278 - 281

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Nano-sized objects exist as engineered tools as well as natural or anthropogenic environmental factors. Recent progress in the field of nanotechnology allows for a deeper understanding of their impact on organisms. Recently, we showed that the size-dependent cell interaction with quantum dots is autophagy-mediated. The potential role of other endo- and exogenous nanoparticles in terms of autophagy is discussed here. Their physical properties should be taken into consideration while constructing delivery systems. Furthermore, we propose several models of targeted nanoparticles delivery. Autophagy can be considered as an additional mechanism providing intracellular selectivity for introduced nanoparticles.

Addendum to:
Quantum Dots for Human Mesenchymal Stem Cells Labeling. A Size-Dependent Autophagy Activation
O. Seleverstov, O. Zabirnyk, M. Zscharnack, L. Bulavina, M. Nowicki, J.M. Heinrich, M. Yezhelyev, F. Emmrich, R. O’Regan and A. Bader
Nano Lett 2006; 12:2826-32

Authors

Olga Zabirnyk

National Institutes of Health

Maksym Yezhelyev

Emory University

Oleksandr Seleverstov

University of Wyoming, Department of Animal Science

We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link: