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Article Addendum
The Roles of Autophagy in Cerebral Ischemia
Faisal Adhami, Aryn Schloemer and Chia-Yi Kuan
volume 3 | issue 1
January/February 2007Pages: 42 - 44
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Recent studies indicate the existence of autophagy in cerebral ischemia, but the functions of autophagy in this setting remain unclear. Here we discuss the role of autophagy in cerebral ischemia based on our own publication and the literature on this subject. We propose that oxidative and endoplasmic reticulum (ER) stresses in cerebral ischemia-hypoxia are potent stimuli of autophagy in neurons. We also reviewed evidence suggesting autophagosomes may have a shorter half-life in neurons and that a fraction of LC3 protein is degraded within autolysosomes, leading to a smaller detectable amount of LC3-II in the brain while there are clear indications of on-going autophagy. Finally, we suggest autophagy is an important modifier of cell death and survival, interacting with necrosis and apoptosis in determining the outcomes and final morphology of deceased neurons.
Authors
Faisal Adhami
Children’s Hospital Medical Center
Aryn Schloemer
Children’s Hospital Medical Center
Chia-Yi Kuan
Children’s Hospital Medical Center
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.