Functions of PI4P and Sterol Glucoside Necessary for the Synthesis of a Nascent Membrane Structure During Pexophagy

Shun-ichi Yamashita, Masahide Oku and Yasuyoshi Sakai

volume 3 | issue 1

January/February 2007
Pages: 35 - 37

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We recently showed that, in the yeast Pichia pastoris, an ergosterol glucoside synthesizing enzyme Atg26 is recruited to the precursor of the pexophagic structure, micropexophagic membrane apparatus (MIPA), under the regulation of phosphatidylinositol 4'-monophosphate (PI4P)-signaling during pexophagy. Atg26 was found to harbor a novel PI4P-binding motif, GRAM domain. Both lipids, PI4P and sterol glucoside, synthesized by PpPik1 and PpAtg26, respectively, were necessary for pexophagy, in the step where the MIPA was formed. In this addendum, we review these findings, and speculate the mechanistic and physiological implications of the functions of these lipids during the autophagic process.

Addendum to:
PI4P-Signaling Pathway for the Synthesis of a Nascent Membrane Structure in Selective Autophagy
S. Yamashita, M. Oku, Y. Wasada, Y. Ano and Y. Sakai
J Cell Biol 2006; 173: 709-17

Authors

Shun-ichi Yamashita

Kyoto University, Kyoto, Japan

Masahide Oku

National Institute for Basic Biology, Okazaki, Japan

Yasuyoshi Sakai

Kyoto University, Kyoto, Japan; CREST, Japan

We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link: