Sign up for Table of Contents Alerts!
Email this page
Print this page
Article Addendum
Autophagy Can Be a Killer Even in Apoptosis-Competent Cells
Audrey Guillon-Munos, Miguel X.P. van Bemmelen and Peter G.H. Clarke
volume 2 | issue 2
April/May/June 2006Pages: 140 - 142
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
Despite abundant evidence for autophagic cell death as a morphological type, the notion that autophagy can actually contribute mechanistically to the cell's death is controversial. In cells capable of apoptosis, autophagic cell death has been dismissed by some authors as a morphologically unusual form of apoptosis. But strong recent evidence for autophagy-mediated death of cells rendered incapable of apoptosis has been criticized on the grounds that this cell death is too artificial to be relevant to normal cells. We here argue from our own and other recent evidence that autophagy can mediate the death even of apoptosis-competent cells.
Addendum to:
Role of Phosphoinositide 3-Kinase in the Autophagic Death of Serum-Deprived PC12 Cells.
A. Guillon-Munos, M.X.P. van Bemmelen and P.G.H. Clarke
Apoptosis 2005; 10:1031-41.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.