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Article Addendum
Autophagy and Inflammatory Cell Death, Partners of Innate Immunity
Michele S. Swanson and Ari B. Molofsky
volume 1 | issue 3
October/November/December 2005Pages: 174 - 176
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Alas, it is the law of the evolutionary jungle that any host defen! se mechanism that efficiently kills microbes also exerts a strong selective pressure for tolerant variants to emerge. A silver lining in this otherwise dark cloud is that pathogens can be exploited as powerful tools to examine host defense mechanisms. Recent studies of the confrontation between macrophages and the opportunistic pathogen Legionella pneumophila have revealed a regulatory mechanism that may link autophagy to pyroptosis. Building from the extensive literature on autophagy, cell death, and innate immunity, we propose here a testable model in which the NOD-LRR protein Naip5 dictates whether macrophages elevate autophagy or pyroptosis as a barrier to infection.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.