The Coagulation-Inflammation Interface: Coagulation Assembly on Leukocytes
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Dario C. Altieri
List price: $149.00 |
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About this bookAlthough leukocytes have been implicated in the initiation and regulation of coagulation for more than two decades, it has been only in recent years that these mechanisms have begun to be dissected at the cellular and molecular level. The highlight of this field of investigation has recently culminated with the biochemical and molecular identification of specialized cell surface receptors on various leukocyte subsets capable of interacting with proteins/proteases of the coagulation cascade. This pathway of receptor-mediated assembly of coagulation on leukocytes has unraveled a fundamental role of these cells in the organization and maintenance of the hemostatic response in vivo. The objective of this new book is to critically review the most recent experimental advances on the cellular and molecular interface between coagulation and inflammation. Emphasis will be placed on the structural and functional analysis of the molecules and receptors mediating the assembly of coagulation on leukocytes and on the functional and signaling consequences of these interactions. The overall goal is to provide an updated perspective on the emerging concept of leukocyte assembly of coagulation as a new signaling cascade participating not only in the hemostatic balance but also in the regulation of inflammatory and vascular cell responses. |
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Table of contentsIntroduction to Primay and Secondary Hemostasis Overview of the Interface Between Inflammation and Coagulation Congulation and Signal Transduction by Tissue Factor Alternative Initiation of Coagulation on Monocyctes Fibronogen-Leukocyte Interaction as a Paradigm of Inflammatory Responses Regulation of Leukocyte-Endothelium Interaction by Fibrogen Bridging Coagulation and Inflammation by Protease Activated Receptor Signaling Factor-Xa-Mediated Vacular Cell Activation and Leukocyte Effectr Functions Urokinase Regulation of Leucocte Migration and Intercellular Communication Anti-Inflammatory Properties of the Anticoagulant Activated Protein C |
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