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Josep M. Argiles

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ISBN: 978-1-57059-545-5
Pub date: 1998-12-01
174 pages
19 figures
14 tables

About this book

This book deals with the molecular basis of diseases involving defects in ubiquitin gene expression and/or synthesis. Among these are Alzheimer\\\\\\\'s and other neurodegenerative diseases, muscle dystrophies, cancer, muscle wasting and autoimmune diseases. The importance of ubiquitin-dependent proteolysis is also described in aging with a special emphasis on the regulation of this ATP-dependent proteolytic system in order to design future therapeutic strategies

Table of contents

Proteolysis: A Pleyade of Systems

The Ubiquitin System and Proteolysis

Alzheimer\\\\\\\'s and Other Neurodegenerative Diseases

Cancer

Muscle Wasting and Dystrophies

Other Pathological States

Aging

The Role of Other Proteolytic Systems in Disease

Cell Injury and Cell Death: Apoptosis

The Regulation of the Ubiquitin System

The Design of Therapeutic Strategies